Research progress of circular RNAs in drug resistance of liver cancer

Liver cancer is one of the common malignant tumors in the world. Although the current treatment methods for liver cancer are increasing, there are still many problems and challenges that need to be solved, such as drug tolerance. Circular RNA is a kind of non-coding RNA that exists stably in the body. In recent years, studies have confirmed that it plays an important role in the occurrence, development, recurrence and drug resistance of liver cancer. This article reviews the impact of circular RNA on the drug resistance of liver cancer and its regulatory mechanism, aiming to provide a reference intervention target for drug resistance in liver cancer, and at the same time provide a stable reference marker for predicting drug resistance.